FOXO4-DRI
Cleared senescent ('zombie') cells in a notable 2017 mouse study. It has never been tested in humans.
FOXO4-DRI is designed to disrupt a protein interaction that keeps senescent cells alive, prompting them to self-destruct.
What the research shows
- A 2017 study in Cell reported better fur, kidney function and fitness in aged mice.
- No human trials have been published.
- Its safety, dosing and effects in people are unknown.
Doses used in research
No human dose has been established. This compound hasn't been through published human dosing trials, so any dose you see online comes from anecdote, not research.
Key sources
- Baar et al., Cell 2017
Last reviewed: November 2026
This page reports what published research and official labels describe. It isn't a recommendation to use any compound. Decisions about any compound should be made with a licensed clinician.